Which cells are primarily responsible for synthesis during the proliferation phase?

During the proliferation phase of wound healing, fibroblasts are primarily responsible for synthesis. These cells play a crucial role in the granulation tissue formation, which is fundamental to the wound healing process. Fibroblasts synthesize collagen and other extracellular matrix components, providing structural support to the healing tissue. This synthesis is essential for wound closure and the overall integrity of the repair process.

Keratinocytes, while important for re-epithelialization, focus on the formation of the outer layer of skin rather than the structural matrix. Endothelial cells are involved in angiogenesis, the formation of new blood vessels, which supports the wound healing process but does not directly contribute to the synthesis of the extracellular matrix. Myofibroblasts are involved in wound contraction and help in closing the wound, but they arise from fibroblasts and their role occurs after the initial synthesis phase.

Thus, fibroblasts are the key players in matrix synthesis during the proliferation phase, facilitating the healing process effectively.